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A new UN US $530 million emergency appeal aims to focus on food aid and tackling the effects of HIV/AIDS in southern Africa.
The request followed a call in 2002 for $656 million to fight the region's worst hunger crisis in a decade.
The UN said that while it planned to help some 2.3 million orphans, it would also tackle the HIV/AIDS pandemic which was badly damaging economies throughout the region.
"Unless [HIV/AIDS] is addressed, most of the gains that we have seen ... will not live very long," regional UNAIDS official, Dan Odallo, said in a statement.
Funding from the appeal is earmarked for the southern African nations of Lesotho, Malawi, Mozambique, Swaziland, Zambia and Zimbabwe.
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