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US president George W Bush said the global HIV/AIDS bill he signed on Tuesday was the "moral duty" of the US in tackling the pandemic.
The five-year US $15 billion plan was designed to help prevent and treat HIV/AIDS in more than a dozen African and Caribbean nations.
"We believe in the value and dignity of every human life," Bush said in a White House statement.
He is expected to use the bill at the "Group of Eight" (G8) summit in France, from 1 to 3 June, to solicit other countries for bigger contributions to the plan.
"I will challenge our partners and our friends to follow our lead and to make a similar commitment made by the US, so we can save even more lives," Bush added.
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